EdenteV2, France, Analysis, bibRecord, 000173

Refining exposure definitions for studies of periodontal disease and systemic disease associations

Identifieur interne : 000173 ( France/Analysis ); précédent : 000172; suivant : 000174

Refining exposure definitions for studies of periodontal disease and systemic disease associations

Auteurs : Ryan T. Demmer [États-Unis] ; Thomas Kocher ; Christian Schwahn ; Henry Völzke [Allemagne] ; David R. Jacobs [Norvège] ; Moïse Desvarieux [États-Unis, France]

Source :

Community dentistry and oral epidemiology [ 0301-5661 ] ; 2008.

RBID : PMC:5651676

Abstract

Background

Substantial variation exists in reported associations between periodontal infections and cardiovascular disease. Imprecise periodontal exposure definitions are possible contributors to this variability. We studied appropriate exposure definitions for studying associations between clinical periodontal disease (PD) and systemic disease.

Methods

Data originate from men and women aged 20–79 enrolled in the Study of Health in Pomerania (SHIP) from 1997–2001. Age and sex-adjusted correlation analysis identified PD definitions with the highest cross-sectional associations with three subclinical markers of systemic disease: plasma fibrinogen (n = 3481), serum hemoglobin A1c (HbA1c) (n = 3480), and common carotid artery intima-media thickness (c-IMT) (n = 1745, age ≥ 45).

Results

In men and women, percent of sites with attachment loss (AL) ≥6 mm and tooth loss both revealed the highest correlation with HbA1c (ρ = 0.11; several other definitions related similarly), while the strongest fibrinogen correlation was observed with percent of sites with pocket depth ≥3 mm (ρ = 0.19). Findings for c-IMT among men were strongest for percent of sites with AL ≥6 mm (ρ = 0.14; several other definitions related similarly) while among women, percent of sites with pocket depth ≥5 or 6 mm had the highest observed correlation (ρ = 0.13).

Conclusions

A range of near optimal definitions varied according to gender and whether the systemic disease marker reflected an acute or chronic situation. Pocket depth was more strongly correlated with the acute marker fibrinogen while attachment and tooth loss tended to be more strongly correlated with the chronic markers, HbA1c, and c-IMT. These findings can be useful in designing future studies investigating the association between PD and systemic disease.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651676

DOI: 10.1111/j.1600-0528.2008.00435.x
PubMed: 18422705
PubMed Central: 5651676

Affiliations:

Allemagne, France, Norvège, États-Unis
État de New York, Île-de-France, Østlandet
New York, Oslo, Paris
Université Columbia

Links to Exploration step

PMC:5651676

Le document en format XML

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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Substantial variation exists in reported associations between periodontal infections and cardiovascular disease. Imprecise periodontal exposure definitions are possible contributors to this variability. We studied appropriate exposure definitions for studying associations between clinical periodontal disease (PD) and systemic disease.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Data originate from men and women aged 20–79 enrolled in the Study of Health in Pomerania (SHIP) from 1997–2001. Age and sex-adjusted correlation analysis identified PD definitions with the highest cross-sectional associations with three subclinical markers of systemic disease: plasma fibrinogen (<italic>n</italic>
 = 3481), serum hemoglobin A1c (HbA1c) (<italic>n</italic>
 = 3480), and common carotid artery intima-media thickness (c-IMT) (<italic>n</italic>
 = 1745, age ≥ 45).</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">In men and women, percent of sites with attachment loss (AL) ≥6 mm and tooth loss both revealed the highest correlation with HbA1c (<italic>ρ</italic>
 = 0.11; several other definitions related similarly), while the strongest fibrinogen correlation was observed with percent of sites with pocket depth ≥3 mm (<italic>ρ</italic>
 = 0.19). Findings for c-IMT among men were strongest for percent of sites with AL ≥6 mm (<italic>ρ</italic>
 = 0.14; several other definitions related similarly) while among women, percent of sites with pocket depth ≥5 or 6 mm had the highest observed correlation (<italic>ρ</italic>
 = 0.13).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">A range of near optimal definitions varied according to gender and whether the systemic disease marker reflected an acute or chronic situation. Pocket depth was more strongly correlated with the acute marker fibrinogen while attachment and tooth loss tended to be more strongly correlated with the chronic markers, HbA1c, and c-IMT. These findings can be useful in designing future studies investigating the association between PD and systemic disease.</p>
</sec>
</div>
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Refining exposure definitions for studies of periodontal disease and systemic disease associations

Refining exposure definitions for studies of periodontal disease and systemic disease associations

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